Some times ago (Xfce-4.6 i think), i created a script that can save the desktop layout, or can change it on the fly.

#######################
export userhome="/home/`whoami`"

/usr/bin/xfce4-panel -x
            killall xfconfd

            rm -rf $userhome/.config/xfce4/
            cp -r /etc/myXfceconfigs/xdg/xfce4/classic/xfce4 $userhome/.config/

setsid sh -c 'xfwm4 --replace ... & :' > /dev/null 2>&1 < /dev/null
setsid sh -c 'xfce4-panel& ... & :' > /dev/null 2>&1 < /dev/null
#######################

Foe Xfce-4.10 changed /usr/bin/xfce4-panel -x for /usr/bin/xfce4-panel -q, but the icon theme won't reload.
I now have to logout and login to get my new layout ok.

Any idea here ?